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Welcome to the new updated XLHLink.com!
  • Connect the symptoms of XLH

    Connect the symptoms.
    Is it XLH?

    Connect the symptoms of XLH
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    Understand how to manage XLH

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    Explore resources for you and your patients

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XLH is rare1

X-linked hypophosphatemia (XLH) is a lifelong, primarily hereditary disease characterized by chronic hypophosphatemia due to increased fibroblast growth factor 23 (FGF23) activity2,3

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Hereditary

XLH is primarily an inherited condition, which means it runs in families.3

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Progressive

New symptoms of XLH may appear as patients get older and can worsen or change over time.4

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Chronic

Individuals with XLH can continue to experience symptoms throughout their lives.4


Take action to help your patients

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Suspect XLH?

Connect their symptoms and accurately diagnose with the right tests.

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Manage XLH

Manage XLH early to prevent progressive bone damage.

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XLH resources and community

From case studies to brochures, find resources for you and your patients to understand more about this rare condition.


Stay connected

Set up time with a representative to talk more about XLH, or sign up for news and information about XLH.

References:

1. Giannini S, Bianchi ML, Rendina D, Massoletti P, Lazzerini D, Brandi ML. Burden of disease and clinical targets in adult patients with X-linked hypophosphatemia. A comprehensive review. Osteoporos Int. 2021;32(10):1937-1949. doi:10.1007/s00198-021-05997-1 2. Carpenter TO, Imel EA, Holm IA, Jan de Beur SM, Insogna KL. A clinician's guide to X-linked hypophosphatemia. J Bone Miner Res. 2011;26(7):1381-1388. doi:10.1002/jbmr.340 3. Ruppe MD. X-linked hypophosphatemia. In: Adam MP, Everman DB, Mirzaa GM, et al., eds. GeneReviews®. Seattle (WA): University of Washington, Seattle; February 9, 2012. Updated April 13, 2017. https://www.ncbi.nlm.nih.gov/books/NBK83985/ 4. Skrinar A, Dvorak-Ewell M, Evins A, et al. The lifelong impact of X-linked hypophosphatemia: results from a burden of disease survey. J Endocr Soc. 2019;3(7):1321-1334. doi:10.1210/js.2018-00365