ADULTS WITH XLH HAVE AN ONGOING ACTIVE DISEASE DUE TO UNRESOLVED SYMPTOMS THAT CAN RESULT IN DISABILITY
Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) is a questionnaire designed to assess pain, stiffness, and physical function in patients with hip and/or knee osteoarthritis. It has been used among patients with different conditions, including low back pain, rheumatoid arthritis, juvenile rheumatoid arthritis, systemic lupus erythematosus, and fibromyalgia.1
Experience of pain may be exacerbated by the development of painful extraosseous calcifications (spine, neck, Achilles, hips) and osteoarthritis.2 Adults with XLH reported increased pain and stiffness.2
The data is taken from an international burden-of-disease study conducted in 232 adult patients with XLH.2
On average, approximately 44% of adults with XLH indicated a history of fractures. The mean age at first fracture was 26.4 years. The average age of adults reporting fractures was 48.4 years and 42% reported at least three fractures.2
Adults with XLH require ongoing disease management to prevent further damage from underlying osteomalacia
1. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). American College of Rheumatology. Accessed March 14, 2022. https://www.rheumatology.org/I-Am-A/Rheumatologist/Research/Clinician-Researchers/Western-Ontario-McMaster-Universities-Osteoarthritis-Index-WOMAC 2. Skrinar A, Dvorak-Ewell M, Evins A, et al. The lifelong impact of X-linked hypophosphatemia: results from a burden of disease survey. J Endocr Soc. 2019;3(7):1321-1334.